This research was motivated by official establishment of ASEAN Economic Community (AEC) on December 31, 2015. The establishment of ASEAN Economic Community (AEC) became a crucial milestone to develop various quantity and quality of economy of Indonesia in ASEAN region. In welcoming ASEAN Economic Community (AEC), the Mayor of Makassar city, represented by the Tourism Office of Makassar proposed to set local cuisine as local wealth of Makassar to Ministry of Tourism of Indonesia to have an Intellectual Property Right in order to be competitive (i.e. Coto Makassar, Pisang Ijo, Pallubasa, Sop Saudara, Konro Bakar, Pallumara, Pisang Epe, Mie Kering, Jalangkote and Konro). This research was conducted to figure out the problems faced by local cuisine entrepreneurs as follow (a) the influence of information technology and innovation on the quality of human resources, (b) the influence of human resources on business performance, (c) the influence of information technology and innovation on business performance, (d) the influence of information technology and innovation on business performance through the quality of human resources. The population of this research was 1.193 employees and 174 respondents as a sample. The sample was taken by using purposive sampling method and analyzed with structural equation model as well as AMOS 21. The result of the research found out the influence of information technology, direct innovation, positive and significant on the quality of human resources, the influence of the quality of human resources, positive and significant on business performance, the influence of direct information technology, positive and insignificant on business performance and the influence of information technology, indirect innovation, positive and insignificant on business performance through the quality of human resources